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KMID : 1146920200500040337
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Journal of Pharmaceutical Investigation
2020 Volume.50 No. 4 p.337 ~ p.347
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Therapeutic targets and drugs for hyper-proliferation of vascular smooth muscle cells
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Huynh Diem Thi Ngoc
Jin Yu-Jin
Heo Kyung-Sun
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Abstract
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Background: Vascular smooth muscle cells (VSMCs) play an important role in the biosynthetic, proliferative, and contractile functions of vessel walls. Hyper-proliferation of VSMCs is a crucial event associated with the pathogenesis of various vascular diseases including hypertension, atherosclerosis, and re-stenosis.
Area covered: A variety of studies have been performed to identify the signaling molecular targets or inhibitory drugs to suppress hyper-proliferation of VSMCs. Emerging studies have highlighted the relevance of targeting various signaling pathways, miRNAs, and post-translational modifications in controlling the hyper-proliferation of VSMCs.
Expert opinion: This review will introduce various inhibitors, a wide range of miRNAs, and different histone deacetylases related to the molecular targets and underlying signaling pathways involved in the regulation of VSMC hyper-proliferation. This will contribute to the development of promising approaches for the treatment of vascular diseases.
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KEYWORD
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Vascular smooth muscle cell, Cell proliferation, Hypertension, Drug target, miRNAs, Deacetylase
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